I have noticed that lots of people are still in the first few weeks or days of Duromine but wanted to ask if anyone has had more long term experience. I took two courses (2 months worth) late last year and lost 10 kgs with virtually no physical effort. There were though all the common symptoms that everyone here is discussing including dry mouth, major sleep problems for the first few days and increased irritability ( and a few more weird ones like changes in urinary frequency and sensation ) Something I think I should share though is that there were definite reductions in effect over time for me. Whilst I started shedding weight very fast at the beginning, by the end of the 8 weeks it was not moving at all, despite having the same other effects (irritability, loss of appetite etc...). I can only assume that my metabolism had adjusted to the new intake level and so it wasn't having the appropriate effect. I don't doubt that I would have probably kept reducing weight if I had kept up a dedicated exercise regime but that didn't happen. My question now though, five months later is that I still need to lose another 10kg to get to a healthy weight level and I have a script for two more courses but unfortunately I cant find any information on whether I can do another Course of Duromine or not? And my GP was also unsure. Does anyone know if there are any restrictions on how many courses you can take or how close together you can take them?