When used as directed in a comprehensive, physician-supervised weight-loss program that includes a low-fat diet and regular exercise, Mazanor and Sanorex can increase weight loss by about an additional 10%. However, weight loss may not be permanent, especially after these drugs are discontinued.

Mazanor and Sanorex limit appetite because of their effects on the hypothalamus, a control center in the brain. The typical dose is 1 mg three times a day an hour before meals, or 2 mg once a day an hour before lunch.

Mazanor and Sanorex are chemically related to amphetamine. Years ago, amphetamine was prescribed for weight loss because it is an appetite suppressant. But it often led to drug abuse, so pharmacologists tinkered with its molecular structure to develop similar -- but safer -- compounds. One is mazindol, the active ingredient in Mazanor and Sanorex. Others include the active ingredients in the over-the-counter products, Acutrim and Dexatrim and in the prescription medications: Tenuate, Fastin, Ionamin, Preludin, Bontril, Plegine, Adipost, Dital, Dyrexan, Melfiat, Prelu-2, Rexigen Forte, and Didrex.

Possible side effects of Mazanor and Sanorex include nervousness, irritability, headache, sweating, dry mouth, nausea, and constipation. Do not take this drug if you are also taking any antidepressant in the chemical family called monoamine oxidase (MAO) inhibitors.